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Emphasize also that sunscreens must be applied 20-30 minutes before going outside and reapplied about every 2 hours, more often if swimming or sweating; lip balm with an SPF of 15 or higher is useful.

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Imiquimod revealed no evidence of mutagenic or clastogenic potential based on the results of five in vitro genotoxicity tests (Ames assay, mouse lymphoma L5178Y assay, Chinese hamster ovary cell chromosome aberration assay, human lymphocyte chromosome aberration assay and SHE cell transformation assay) and three in vivo genotoxicity tests (rat and hamster bone marrow cytogenetics assay and a mouse dominant lethal test).

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Choice is based on the experience of the healthcare provider, patient preference, cost of treatment, adverse effects and the feasibility of a given procedure (), in addition to the absence of definitive evidence which shows which therapy is superior ().

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